Incannex Announces It Has Received Patient-Reported Outcomes And Phase 2 Efficacy Data For IHL-42X In Obstructive Sleep Apnoea With 89.5% Of Participants Describing A Meaningful Change to Their Lives

Incannex Healthcare Inc. (NASDAQ:IXHL), a clinical-stage pharmaceutical company developing innovative combination therapies for prevalent medical conditions, today announced new patient-reported outcome findings from a subset of participants in its RePOSA Phase 2 trial of IHL-42X for the treatment of obstructive sleep apnoea (OSA). These new insights, collected through structured exit interviews, add to an already compelling data package highlighting the significant potential of IHL-42X to improve both clinical and patient-centric outcomes in individuals living with OSA.

The exit interviews were conducted in alignment with FDA guidance on Patient-Focused Drug Development (PFDD) and aimed to qualitatively assess patient experience, including the impact of IHL-42X on their sleep and quality of life. The interviews were completed prior to unblinding and included subjects from all three arms of the trial—placebo, low-dose IHL-42X, and high-dose IHL-42X.

Key findings from the exit interviews include:

• 57.6% of participants reported a perceived improvement in their OSA
  
   
• 89.5% of those reporting improvement described the change as meaningful to their lives
  
   
• Reported benefits included: improved sleep quality, feeling more refreshed in the morning, reduced daytime sleepiness and fatigue, fewer cognitive disturbances, and greater ease in completing daily responsibilities

Patients reported being motivated to participate in the trial due to a desire for improved health, better sleep, and access to alternatives to PAP (positive airway pressure) therapy. These patient insights add important context to the robust clinical data from the RePOSA Phase 2 trial.